Quatrefolic® is a new generation folate with increased solubility and bioavailability. Medlab Quatrefolic® contains levomefolate glucosamine which is a form of biologically active folate, 5-methyltetrahydrofolate (5-MTHF). Dietary folate and synthetic folic acid are not biologically active and need to be converted into 5-MTHF in a multistep process, requiring the enzyme methylenetetrahydrofolate reductase (MTHFR). Individuals with polymorphic forms of this enzyme cannot convert adequate amounts of biologically active folate. 5-MTHF can bypass the MTHFR enzyme to meet nutritional demands. Folate is essential for DNA synthesis, cell division, red blood cell production and homocysteine metabolism. Demands for folate increase during pregnancy due to increased requirements for foetal growth and development.