BifidoBiotic™ is a scientifically formulated combination of bifidobacteria species to support the health and function of the intestinal microbiome across the lifespan. Bifidobacteria species may help to re-regulate pro-inflammatory cytokine levels and support a healthy immune response. Bifidobacterium species have been documented to decrease in number, with the increasing age of the host, contributing to a decline in immune system efficacy associated with ageing. Bifidobacterium longum, and Bifidobacterium bifidum influence beneficial host-gene expression of immune cells in the intestinal mucosa. Bifidobacterium infantis has been demonstrated in clinical trials to normalise intestinal permeability, improve gastrointestinal health conditions and improve the symptoms of diarrhoea-associated irritable bowel syndrome.